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Serum levels of inorganic phosphorus may increase slightly in patients with inadequate secretion of endogenous GH, CKD, or TS during Nutropin AQ therapy due to metabolic activity associated with bone growth as well as increased tubular reabsorption of phosphate by the kidney. Patient Counseling Information Patients being treated with Nutropin AQ (and/or their parents) should be informed about the potential benefits and risks associated with Nutropin AQ treatment, including a review of the contents of the instructions FOR USE. Nutropin AQ is a sterile liquid intended for subcutaneous administration. Reeds also offers certified diamonds and beautiful value-priced jewelry to fit discerning shoppers of all budgets. The amino acid sequence of the product is identical to that of pituitary-derived hGH. Nutropin AQ - Clinical Pharmacology Mechanism of Action Somatropin (as well as endogenous growth hormone) binds to dimeric growth hormone receptors located within the cell membranes of target tissue cells resulting in intracellular signal transduction and a host of pharmacodynamic effects. In childhood-onset subjects, there was an increase of median fasting insulin level in the Nutropin.025 mg/kg/day group from.0 U/mL at baseline.0 U/mL at Month 12, in the Nutropin.0125 mg/kg/day group from.5 U/mL.0 U/mL, and in the placebo. Pediatric Patients Growth Hormone Deficiency (GHD) Injection site discomfort has been reported. A Member of the Roche Group 1 DNA Way South San Francisco, CA Nutropin AQ is a registered trademark of Genentech, Inc. Hypersensitivity Nutropin AQ is contraindicated in patients with a known hypersensitivity to somatropin or any of its excipients. If treatment with somatropin is initiated, these patients should be carefully monitored for development of neoplasms.